Multi-Electrode Architecture Modeling and Optimization for Homogeneous Electroporation of Large Volumes of Tissue

Electroporation is a phenomenon that consists of increasing the permeability cell membrane by means high-intensity electric field application. Nowadays, its clinical application to cancer treatment one most relevant branches within many areas electroporation. In this area, it essential apply homogeneous treatments achieve complete removal tumors and avoid relapse. It necessary an optimized transmembrane potential at each point tissue homogenous appropriated orientation. Nevertheless, biological tissues are composed wide variety, heterogeneous anisotropic structures and, consequently, predicting applied distribution complex. Consequently, applying parallel-needle electrodes single-output generators, predictable difficult obtain, often requiring several repositioning/application processes may leave untreated areas. This paper proposes use multi-electrode structure range vectors enhance homogeneity treatment. To aim, new parallel-plate configuration proposed improve in combination with multiple-output generator. One method for optimizing pattern studied, simulation experimental results presented discussed, proving feasibility approach.